Echoviruses bind heparan sulfate at the cell surface.
نویسندگان
چکیده
Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.
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عنوان ژورنال:
- Journal of virology
دوره 75 10 شماره
صفحات -
تاریخ انتشار 2001